Synthesis and Antihypertensive Activity of Some N-{4-(6-Chloro-5-nitro-1- [2'--(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazol-2yl-}-phenyl)- 3-(substituted-phenyl)-acryl amides
نویسندگان
چکیده
A new series of N-{4-(6-Chloro-5-nitro-1-[2'--(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1Hbenzoimidazol-2yl-}-phenyl)-3-(substituted-phenyl)-acryl amide derivatives [1-8] has been synthesized and subjected to evaluate their antihypertensive activity. All the synthesized compounds of the series displayed, remarkable activity in comparison to standard drug(losratan ). Many Schiff bases were prepared by condensation reaction of nitro compound containing biphenyl tetrazole with aromatic aldehydes and ketone derivatives were prepared by Schiff base. The synthesized compounds were screened for AT1 Angiotension (A II) Receptor Antagonist activity.
منابع مشابه
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF SOME BENZYLIDENE-(2-{5, 6-SUBSTITUTED-1-[2-(1H-TETRAZOL-5-yl)-BIPHENYL-4- YLMETHYL]-1H-BENZOIMIDAZOL-2-YL}-PHENYL-AMINE IN THE PRESENCES OF BF3·OET2 CATALYSTS AS ANTIHYPERTENSIVE AGENTS
A series of Benzylidene-(2-{5, 6-substituted-1-[2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]1H-benzoimidazol-2-yl}-phenyl-amine have been synthesized by 4'-{2-[2-(Benzylideneamino)-phenyl] 5, 6-substitutedbenzimidazol-1-yl}-biphenyl-2-carbonitrile.Preliminary screening of the title compounds for antihypertensive activity was performed. Only one of the compound was found to possess antihypertensive...
متن کاملBenzimidazoles derivatives with (2-{6-Chloro-5-nitro-1-[2-(1H-tetrazol-5-yl) biphenyl- 4-ylmethyl] 1H-benzoimidazol-2-yl}-phenyl)-(substituted-benzylidene)-amine with potential angiotensin II receptor antagonists as antihypertensive activity
Mukesh C. Sharma Dept. of Pharmaceutical Sciences, Dr.Hari Singh Gour University Sagar (M.P) 470003 India Department of Chemistry Yadhunath Mahavidyalya Bhind (M.P) 477001 India Email: [email protected] Abstract In this study we have synthesized some Benzimidazole derivatives (2-{6Chloro-5-nitro-1-[2-(1H-tetrazol-5-yl) biphenyl-4-ylmethyl] 1Hbenzoimidazol-2-yl}-phenyl)-(Substituted-benzyl...
متن کاملA rational approach for synthesis, characterization and antihypertensive activity evaluation of 1-(4-{5-amino-6-fluoro-1-[2'-(2H-tetrazole-5-yl)- biphenyl-4-ylmethyl]-1H-benzoimidazol-2-yl}-phenyl)-3-chloro-4- (substituted -phenyl)-azetidin-2-ones
A new series of 1-(4-{5-Amino-6-fluoro-1-[2'-(2H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-1Hbenzoimidazol-2-yl}-phenyl)-3-chloro-4-(Substituted -phenyl)-azetidin-2-one derivatives MCS 06[1-15] has been synthesized and subjected to evaluate their antihypertensive activity. All the synthesized compounds of the series elicit remarkable activity in comparison to standard drug (Losartan). Structures of ...
متن کاملSynthesis and pharmacological activity of 2-(2-substituted-phenyl)-3-(4-{1-[2- (1H-tetrazol-5-yl)-biphenyl-4-ylmethyl])-1H-benzoimidazol-2-yl}-phenyl)- thiazolidin-4-ones
An easy and efficient method to obtain Schiff bases of [2-(2-substituted-phenyl)-3-(4-{1-[2-(1Htetrazol-5-yl)-biphenyl-4-ylmethyl])-1H benzoimidazol-2-yl}-phenyl)thiazolidin-4-one] using different aromatic aldehydes. Reaction mixture of Schiff base (0.01 mol) and mercaptoacetic acid (0.05 mol) dissolved in dioxane (50 ml), anhydrous zinc chloride (0.008 mol) was added and refluxed for 12 hrs. T...
متن کاملEfficient Synthesis and Pharmacological Evaluation of 3-(4-{5-Amino-6- fluoro-1-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazol-2-yl}- phenyl) -2-(substituted) - thiazolidin-4-one as Potent Antihypertensive Agents
Several substituted-benzimidazole 3-(4-{5-Amino-6-fluoro-1-[2'-(1H-tetrazole-5-yl)-biphenyl-4ylmethyl]-1H-benzoimidazol-2-yl}-phenyl) -2-(substituted)thiazolidin-4-one were synthesized by condensation of various steps with various substituted aryl aldehydes reaction. Elemental analysis, IR, 1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized and ...
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